Sustained intrinsic WNT and BMP4 activation impairs hESC differentiation to definitive endoderm and drives the cells towards extra-embryonic mesoderm

We identified a human embryonic stem cell subline that fails to respond to the differentiation cues needed to obtain endoderm derivatives, differentiating instead into extra-embryonic mesoderm. RNA-sequencing analysis showed that the subline has hyperactivation of the WNT and BMP4 signalling. Modula...

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Publicat a:Sci Rep
Autors principals: Markouli, C., De Deckersberg, E. Couvreu, Dziedzicka, D., Regin, M., Franck, S., Keller, A., Gheldof, A., Geens, M., Sermon, K., Spits, C.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050086/
https://ncbi.nlm.nih.gov/pubmed/33859268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87547-7
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