Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

Low differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell cultures, as well as transcriptomic profiling, to investigate how variabili...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dziedzicka, Dominika, Tewary, Mukul, Keller, Alexander, Tilleman, Laurentijn, Prochazka, Laura, Östblom, Joel, Couvreu De Deckersberg, Edouard, Markouli, Christina, Franck, Silvie, Van Nieuwerburgh, Filip, Spits, Claudia, Zandstra, Peter W., Sermon, Karen, Geens, Mieke
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969605/
https://ncbi.nlm.nih.gov/pubmed/33731744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85447-4
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