Uncovering low-level mosaicism in human embryonic stem cells using high throughput single cell shallow sequencing

Human pluripotent stem cells (hPSCs) have significant levels of low-grade genetic mosaicism, which commonly used techniques fail to detect in bulk DNA. These copy number variations remain a hurdle for the clinical translation of hPSC, as their effect in vivo ranges from unknown to dangerous, and the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Keller, Alexander, Tilleman, Laurentijn, Dziedzicka, Dominika, Zambelli, Filippo, Sermon, Karen, Van Nieuwerburgh, Filip, Spits, Claudia, Geens, Mieke
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796059/
https://ncbi.nlm.nih.gov/pubmed/31619727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51314-6
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