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Uncovering low-level mosaicism in human embryonic stem cells using high throughput single cell shallow sequencing
Human pluripotent stem cells (hPSCs) have significant levels of low-grade genetic mosaicism, which commonly used techniques fail to detect in bulk DNA. These copy number variations remain a hurdle for the clinical translation of hPSC, as their effect in vivo ranges from unknown to dangerous, and the...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6796059/ https://ncbi.nlm.nih.gov/pubmed/31619727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51314-6 |
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