Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability

Human embryonic stem cells (hESC) show great promise for clinical and research applications, but their well-known proneness to genomic instability hampers the development to their full potential. Here, we demonstrate that medium acidification linked to culture density is the main cause of DNA damage...

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Udgivet i:Stem Cell Reports
Main Authors: Jacobs, Kurt, Zambelli, Filippo, Mertzanidou, Afroditi, Smolders, Ilse, Geens, Mieke, Nguyen, Ha Thi, Barbé, Lise, Sermon, Karen, Spits, Claudia
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788786/
https://ncbi.nlm.nih.gov/pubmed/26923824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.01.015
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