Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells

Summary: In this study, we deep-sequenced the mtDNA of human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) and their source cells and found that the majority of variants pre-existed in the cells used to establish the lines. Early-passage hESCs carried few and low-load heteroplasmic...

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Principais autores:	Filippo Zambelli, Joke Mertens, Dominika Dziedzicka, Johan Sterckx, Christina Markouli, Alexander Keller, Philippe Tropel, Laura Jung, Stephane Viville, Hilde Van de Velde, Mieke Geens, Sara Seneca, Karen Sermon, Claudia Spits
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2018-07-01
叢編:	Stem Cell Reports
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2213671118302248
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