Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem Cells

In this study, we deep-sequenced the mtDNA of human embryonic and induced pluripotent stem cells (hESCs and hiPSCs) and their source cells and found that the majority of variants pre-existed in the cells used to establish the lines. Early-passage hESCs carried few and low-load heteroplasmic variants...

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Опубликовано в: :Stem Cell Reports
Главные авторы: Zambelli, Filippo, Mertens, Joke, Dziedzicka, Dominika, Sterckx, Johan, Markouli, Christina, Keller, Alexander, Tropel, Philippe, Jung, Laura, Viville, Stephane, Van de Velde, Hilde, Geens, Mieke, Seneca, Sara, Sermon, Karen, Spits, Claudia
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117474/
https://ncbi.nlm.nih.gov/pubmed/29910126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.05.007
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