NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CA(H1047R) homozygosity in pluripotent stem cells

Activating PIK3CA mutations are known ‘drivers’ of human cancer and developmental overgrowth syndromes. We recently demonstrated that the ‘hotspot’ PIK3CA(H1047R) variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem cells (hPSCs). In this study, we combine hi...

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發表在:Dis Model Mech
Main Authors: Madsen, Ralitsa R., Longden, James, Knox, Rachel G., Robin, Xavier, Völlmy, Franziska, Macleod, Kenneth G., Moniz, Larissa S., Carragher, Neil O., Linding, Rune, Vanhaesebroeck, Bart, Semple, Robert K.
格式: Artigo
語言:Inglês
出版: The Company of Biologists Ltd 2021
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969366/
https://ncbi.nlm.nih.gov/pubmed/33514588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.048298
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