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Generation of targeted homozygosity in the genome of human induced pluripotent stem cells
When loss of heterozygosity (LOH) is correlated with loss or gain of a disease phenotype, it is often necessary to identify which gene or genes are involved. Here, we developed a region-specific LOH-inducing system based on mitotic crossover in human induced pluripotent stem cells (hiPSCs). We first...
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| Pubblicato in: | PLoS One |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6894808/ https://ncbi.nlm.nih.gov/pubmed/31805151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0225740 |
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