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Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon
Induced pluripotent stem cells (iPSCs) have been generated from somatic cells by transgenic expression of Oct4, Sox2, Klf4, and cMyc. A major difficulty in the application of this technology for regenerative medicine, however, is the delivery of reprogramming factors. Whereas retroviral transduction...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2677165/ https://ncbi.nlm.nih.gov/pubmed/19337237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1323 |
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