NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CA(H1047R) homozygosity in pluripotent stem cells

Activating PIK3CA mutations are known ‘drivers’ of human cancer and developmental overgrowth syndromes. We recently demonstrated that the ‘hotspot’ PIK3CA(H1047R) variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem cells (hPSCs). In this study, we combine hi...

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Detalles Bibliográficos
Publicado en:Dis Model Mech
Main Authors: Madsen, Ralitsa R., Longden, James, Knox, Rachel G., Robin, Xavier, Völlmy, Franziska, Macleod, Kenneth G., Moniz, Larissa S., Carragher, Neil O., Linding, Rune, Vanhaesebroeck, Bart, Semple, Robert K.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969366/
https://ncbi.nlm.nih.gov/pubmed/33514588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.048298
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