NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CA(H1047R) homozygosity in pluripotent stem cells

Activating PIK3CA mutations are known ‘drivers’ of human cancer and developmental overgrowth syndromes. We recently demonstrated that the ‘hotspot’ PIK3CA(H1047R) variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem cells (hPSCs). In this study, we combine hi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Dis Model Mech
Päätekijät: Madsen, Ralitsa R., Longden, James, Knox, Rachel G., Robin, Xavier, Völlmy, Franziska, Macleod, Kenneth G., Moniz, Larissa S., Carragher, Neil O., Linding, Rune, Vanhaesebroeck, Bart, Semple, Robert K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Company of Biologists Ltd 2021
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969366/
https://ncbi.nlm.nih.gov/pubmed/33514588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.048298
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