Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome

Pumilio paralogs, PUM1 and PUM2, are sequence-specific RNA-binding proteins that are essential for vertebrate development and neurological functions. PUM1&2 negatively regulate gene expression by accelerating degradation of specific mRNAs. Here, we determined the repression mechanism and impact...

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Pubblicato in:RNA
Autori principali: Enwerem, Isioma I.I., Elrod, Nathan D., Chang, Chung-Te, Lin, Ai, Ji, Ping, Bohn, Jennifer A., Levdansky, Yevgen, Wagner, Eric J., Valkov, Eugene, Goldstrohm, Aaron C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962487/
https://ncbi.nlm.nih.gov/pubmed/33397688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.078436.120
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