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Evaluation of Combination Strategies for the A(2A)R Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model
BACKGROUND: Adenosine receptor type 2 (A(2A)R) inhibitor, AZD4635, has been shown to reduce immunosuppressive adenosine effects within the tumor microenvironment (TME) and to enhance the efficacy of checkpoint inhibitors across various syngeneic models. This study aims at investigating anti-tumor ac...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Front Immunol |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Frontiers Media S.A.
2021
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7962275/ https://ncbi.nlm.nih.gov/pubmed/33737925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.617316 |
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