Evaluation of Combination Strategies for the A(2A)R Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model

BACKGROUND: Adenosine receptor type 2 (A(2A)R) inhibitor, AZD4635, has been shown to reduce immunosuppressive adenosine effects within the tumor microenvironment (TME) and to enhance the efficacy of checkpoint inhibitors across various syngeneic models. This study aims at investigating anti-tumor ac...

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Detalhes bibliográficos
Publicado no:Front Immunol
Principais autores: Voronova, Veronika, Peskov, Kirill, Kosinsky, Yuri, Helmlinger, Gabriel, Chu, Lulu, Borodovsky, Alexandra, Woessner, Richard, Sachsenmeier, Kris, Shao, Wenlin, Kumar, Rakesh, Pouliot, Gayle, Merchant, Melinda, Kimko, Holly, Mugundu, Ganesh
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962275/
https://ncbi.nlm.nih.gov/pubmed/33737925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.617316
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