Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

BACKGROUND: Numerous oncology combination therapies involving modulators of the cancer immune cycle are being developed, yet quantitative simulation models predictive of outcome are lacking. We here present a model-based analysis of tumor size dynamics and immune markers, which integrates experiment...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Kosinsky, Yuri, Dovedi, Simon J., Peskov, Kirill, Voronova, Veronika, Chu, Lulu, Tomkinson, Helen, Al-Huniti, Nidal, Stanski, Donald R., Helmlinger, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830328/
https://ncbi.nlm.nih.gov/pubmed/29486799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-018-0327-9
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