Apelin Rejuvenates Aged Human Mesenchymal Stem Cells by Regulating Autophagy and Improves Cardiac Protection After Infarction

The protective effects of mesenchymal stem cell (MSC)-based therapy for myocardial infarction (MI) are largely hampered as they age. Apelin is an endogenous ligand of its receptor APJ and plays an essential role in regulating multiple biological activities including MSC proliferation and survival. I...

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Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: Zhang, Hao, Zhao, Chengling, Jiang, Guojun, Hu, Bei, Zheng, Huifeng, Hong, Yimei, Cui, Zhen, Shi, Linli, Li, Xin, Lin, Fang, Ding, Yue, Wei, Lu, Li, Mimi, Liang, Xiaoting, Zhang, Yuelin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7960672/
https://ncbi.nlm.nih.gov/pubmed/33738284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.628463
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