Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in experimental pulmonary fibrosis

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an age-related disease with no cure. Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy for IPF treatment. Nevertheless, MSCs derived from patients with IPF (IPF-MSCs) become senescent, thereby reducing their beneficial effect...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Shi, Linli, Han, Qian, Hong, Yimei, Li, Weifeng, Gong, Gencheng, Cui, Jiangyu, Mao, Mengmeng, Liang, Xiaoting, Hu, Bei, Li, Xin, Luo, Qun, Zhang, Yuelin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905557/
https://ncbi.nlm.nih.gov/pubmed/33632305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02215-x
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