Apelin Rejuvenates Aged Human Mesenchymal Stem Cells by Regulating Autophagy and Improves Cardiac Protection After Infarction

The protective effects of mesenchymal stem cell (MSC)-based therapy for myocardial infarction (MI) are largely hampered as they age. Apelin is an endogenous ligand of its receptor APJ and plays an essential role in regulating multiple biological activities including MSC proliferation and survival. I...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Zhang, Hao, Zhao, Chengling, Jiang, Guojun, Hu, Bei, Zheng, Huifeng, Hong, Yimei, Cui, Zhen, Shi, Linli, Li, Xin, Lin, Fang, Ding, Yue, Wei, Lu, Li, Mimi, Liang, Xiaoting, Zhang, Yuelin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7960672/
https://ncbi.nlm.nih.gov/pubmed/33738284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.628463
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