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Nonequilibrium dynamics and action at a distance in transcriptionally driven DNA supercoiling
We study the effect of transcription on the kinetics of DNA supercoiling in three dimensions by means of Brownian dynamics simulations of a single-nucleotide–resolution coarse-grained model for double-stranded DNA. By explicitly accounting for the action of a transcribing RNA polymerase (RNAP), we c...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7958449/ https://ncbi.nlm.nih.gov/pubmed/33649196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905215118 |
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