Ephemeral Protein Binding to DNA Shapes Stable Nuclear Bodies and Chromatin Domains

Fluorescence microscopy reveals that the contents of many (membrane-free) nuclear bodies exchange rapidly with the soluble pool while the underlying structure persists; such observations await a satisfactory biophysical explanation. To shed light on this, we perform large-scale Brownian dynamics sim...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Brackley, Chris A., Liebchen, Benno, Michieletto, Davide, Mouvet, Francois, Cook, Peter R., Marenduzzo, Davide
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Nucleic Acids and Genome Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375003/
https://ncbi.nlm.nih.gov/pubmed/28355537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.01.025
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