Simulating topological domains in human chromosomes with a fitting-free model

We discuss a polymer model for the 3D organization of human chromosomes. A chromosome is represented by a string of beads, with each bead being “colored” according to 1D bioinformatic data (e.g., chromatin state, histone modification, GC content). Individual spheres (representing bi- and multi-valen...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleus
Prif Awduron: Brackley, C. A., Michieletto, D., Mouvet, F., Johnson, J., Kelly, S., Cook, P. R., Marenduzzo, D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2016
Pynciau:
Extra View
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120592/
https://ncbi.nlm.nih.gov/pubmed/27841970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2016.1239684
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