mTORC1-chaperonin CCT signaling regulates m(6)A RNA methylation to suppress autophagy

Mechanistic Target of Rapamycin Complex 1 (mTORC1) is a central regulator of cell growth and metabolism that senses and integrates nutritional and environmental cues with cellular responses. Recent studies have revealed critical roles of mTORC1 in RNA biogenesis and processing. Here, we find that th...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tang, Hong-Wen, Weng, Jui-Hsia, Lee, Wen Xing, Hu, Yanhui, Gu, Lei, Cho, Sungyun, Lee, Gina, Binari, Richard, Li, Cathleen, Cheng, Min En, Kim, Ah-Ram, Xu, Jun, Shen, Zhangfei, Xu, Chiwei, Asara, John M., Blenis, John, Perrimon, Norbert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958400/
https://ncbi.nlm.nih.gov/pubmed/33649236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021945118
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