Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1

Pancreatic ductal adenocarcinoma (PDA) is a lethal, therapy-resistant cancer that thrives in a highly desmoplastic, nutrient-deprived microenvironment. Several studies investigated the effects of depriving PDA of either glucose or glutamine alone. However, the consequences on PDA growth and metaboli...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Tsai, Pei-Yun, Lee, Min-Sik, Jadhav, Unmesh, Naqvi, Insia, Madha, Shariq, Adler, Ashley, Mistry, Meeta, Naumenko, Sergey, Lewis, Caroline A., Hitchcock, Daniel S., Roberts, Frederick R., DelNero, Peter, Hank, Thomas, Honselmann, Kim C., Morales Oyarvide, Vicente, Mino-Kenudson, Mari, Clish, Clary B., Shivdasani, Ramesh A., Kalaany, Nada Y.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958225/
https://ncbi.nlm.nih.gov/pubmed/33653947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003014118
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