Identification of Potent Reverse Indazole Inhibitors for HPK1

[Image: see text] Hematopoietic progenitor kinase (HPK1), a negative regulator of TCR-mediated T-cell activation, has been recognized as a novel antitumor immunotherapy target. Structural optimization of kinase inhibitor 4 through a systematic two-dimensional diversity screen of pyrazolopyridines le...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Yu, Elsie C., Methot, Joey L., Fradera, Xavier, Lesburg, Charles A., Lacey, Brian M., Siliphaivanh, Phieng, Liu, Ping, Smith, Dustin M., Xu, Zangwei, Piesvaux, Jennifer A., Kawamura, Shuhei, Xu, Haiyan, Miller, J. Richard, Bittinger, Mark, Pasternak, Alexander
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2021
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957946/
https://ncbi.nlm.nih.gov/pubmed/33738073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00672
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