Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function

Hematopoietic progenitor kinase 1 (HPK1), a hematopoietic cell-specific Ste20-related serine/threonine kinase, is a negative regulator of signal transduction in immune cells, including T cells, B cells, and dendritic cells (DCs). In mice, HPK1 deficiency subverts inhibition of the anti-tumor immune...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wang, Yun, Zhang, Kelvin, Georgiev, Peter, Wells, Steven, Xu, Haiyan, Lacey, Brian M., Xu, Zangwei, Laskey, Jason, Mcleod, Robbie, Methot, Joey L., Bittinger, Mark, Pasternak, Alexander, Ranganath, Sheila
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714195/
https://ncbi.nlm.nih.gov/pubmed/33270695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0243145
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