Identification of Potent Reverse Indazole Inhibitors for HPK1

[Image: see text] Hematopoietic progenitor kinase (HPK1), a negative regulator of TCR-mediated T-cell activation, has been recognized as a novel antitumor immunotherapy target. Structural optimization of kinase inhibitor 4 through a systematic two-dimensional diversity screen of pyrazolopyridines le...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Yu, Elsie C., Methot, Joey L., Fradera, Xavier, Lesburg, Charles A., Lacey, Brian M., Siliphaivanh, Phieng, Liu, Ping, Smith, Dustin M., Xu, Zangwei, Piesvaux, Jennifer A., Kawamura, Shuhei, Xu, Haiyan, Miller, J. Richard, Bittinger, Mark, Pasternak, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2021
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957946/
https://ncbi.nlm.nih.gov/pubmed/33738073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00672
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