Identification of Potent Reverse Indazole Inhibitors for HPK1

[Image: see text] Hematopoietic progenitor kinase (HPK1), a negative regulator of TCR-mediated T-cell activation, has been recognized as a novel antitumor immunotherapy target. Structural optimization of kinase inhibitor 4 through a systematic two-dimensional diversity screen of pyrazolopyridines le...

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Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Yu, Elsie C., Methot, Joey L., Fradera, Xavier, Lesburg, Charles A., Lacey, Brian M., Siliphaivanh, Phieng, Liu, Ping, Smith, Dustin M., Xu, Zangwei, Piesvaux, Jennifer A., Kawamura, Shuhei, Xu, Haiyan, Miller, J. Richard, Bittinger, Mark, Pasternak, Alexander
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2021
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957946/
https://ncbi.nlm.nih.gov/pubmed/33738073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00672
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