Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)

[Image: see text] Protein arginine methyltransferase 5 (PRMT5) belongs to a family of enzymes that regulate the posttranslational modification of histones and other proteins via methylation of arginine. Methylation of histones is linked to an increase in transcription and regulates a manifold of fun...

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Publicado en:ACS Med Chem Lett
Main Authors: Palte, Rachel L., Schneider, Sebastian E., Altman, Michael D., Hayes, Robert P., Kawamura, Shuhei, Lacey, Brian M., Mansueto, My Sam, Reutershan, Michael, Siliphaivanh, Phieng, Sondey, Christopher, Xu, Haiyan, Xu, Zangwei, Ye, Yingchun, Machacek, Michelle R.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2020
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488283/
https://ncbi.nlm.nih.gov/pubmed/32944135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00525
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