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Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)

[Image: see text] Protein arginine methyltransferase 5 (PRMT5) belongs to a family of enzymes that regulate the posttranslational modification of histones and other proteins via methylation of arginine. Methylation of histones is linked to an increase in transcription and regulates a manifold of fun...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Palte, Rachel L., Schneider, Sebastian E., Altman, Michael D., Hayes, Robert P., Kawamura, Shuhei, Lacey, Brian M., Mansueto, My Sam, Reutershan, Michael, Siliphaivanh, Phieng, Sondey, Christopher, Xu, Haiyan, Xu, Zangwei, Ye, Yingchun, Machacek, Michelle R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2020
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488283/
https://ncbi.nlm.nih.gov/pubmed/32944135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00525
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