Cryo-EM Density Map Fitting Driven In-Silico Structure of Human Soluble Guanylate Cyclase (hsGC) reveals functional aspects of inter-domain cross talk upon NO binding

The human soluble Guanylate Cyclase (hsGC) is a heterodimeric heme-containing enzyme which regulates many important physiological processes. In eukaryotes, hsGC is the only known receptor for nitric oxide (NO) signaling. Improper NO signaling results in various disease conditions such as neurodegene...

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Veröffentlicht in:J Mol Graph Model
Hauptverfasser: Khalid, Rana Rehan, Maryam, Arooma, Fadouloglou, Vasiliki E., Siddiqi, Abdul Rauf, Zhang, Yang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956049/
https://ncbi.nlm.nih.gov/pubmed/31055154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2019.04.009
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