Cryo-EM Density Map Fitting Driven In-Silico Structure of Human Soluble Guanylate Cyclase (hsGC) reveals functional aspects of inter-domain cross talk upon NO binding

The human soluble Guanylate Cyclase (hsGC) is a heterodimeric heme-containing enzyme which regulates many important physiological processes. In eukaryotes, hsGC is the only known receptor for nitric oxide (NO) signaling. Improper NO signaling results in various disease conditions such as neurodegene...

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Publicado en:J Mol Graph Model
Main Authors: Khalid, Rana Rehan, Maryam, Arooma, Fadouloglou, Vasiliki E., Siddiqi, Abdul Rauf, Zhang, Yang
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956049/
https://ncbi.nlm.nih.gov/pubmed/31055154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2019.04.009
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