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Cryo-EM Density Map Fitting Driven In-Silico Structure of Human Soluble Guanylate Cyclase (hsGC) reveals functional aspects of inter-domain cross talk upon NO binding
The human soluble Guanylate Cyclase (hsGC) is a heterodimeric heme-containing enzyme which regulates many important physiological processes. In eukaryotes, hsGC is the only known receptor for nitric oxide (NO) signaling. Improper NO signaling results in various disease conditions such as neurodegene...
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| Publicado no: | J Mol Graph Model |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7956049/ https://ncbi.nlm.nih.gov/pubmed/31055154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2019.04.009 |
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