Bicarbonate Modulates Photoreceptor Guanylate Cyclase (ROS-GC) Catalytic Activity

By generating the second messenger cGMP in retinal rods and cones, ROS-GC plays a central role in visual transduction. Guanylate cyclase-activating proteins (GCAPs) link cGMP synthesis to the light-induced fall in [Ca(2+)](i) to help set absolute sensitivity and assure prompt recovery of the respons...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Duda, Teresa, Wen, Xiao-Hong, Isayama, Tomoki, Sharma, Rameshwar K., Makino, Clint L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409265/
https://ncbi.nlm.nih.gov/pubmed/25767116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.650408
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