S100B Serves as a Ca(2+) Sensor for ROS-GC1 Guanylate Cyclase in Cones but Not in Rods of the Murine Retina

Rod outer segment membrane guanylate cyclase (ROS-GC1) is a bimodal Ca(2+) signal transduction switch. Lowering [Ca(2+)](i) from 200 to 20 nM progressively turns it “ON” as does raising [Ca(2+)](i) from 500 to 5000 nM. The mode operating at lower [Ca(2+)](i) plays a vital role in phototransduction i...

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Bibliografiske detaljer
Main Authors: Wen, Xiao-Hong, Duda, Teresa, Pertzev, Alexandre, Venkataraman, Venkateswar, Makino, Clint L., Sharma, Rameshwar K.
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2012
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434333/
https://ncbi.nlm.nih.gov/pubmed/22508049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000338496
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