Kras-deficient T cells attenuate graft-versus-host disease but retain graft-versus-leukemia activity

Acute graft-versus-host disease (aGVHD) is one major serious complication that is induced by alloreactive donor T cells recognizing host antigens and limits the success of allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the current studies, we identified a critical role of Kras in...

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Udgivet i:J Immunol
Main Authors: Luo, Lan, Chen, Yuhong, Chen, Xiao, Zheng, Yongwei, Zhou, Vivian, Yu, Mei, Burns, Robert, Zhu, Wen, Fu, Guoping, Felix, Juan C., Hartley, Christopher, Damnernsawad, Alisa, Zhang, Jing, Wen, Renren, Drobyski, Williams R., Gao, Chunji, Wang, Demin
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955895/
https://ncbi.nlm.nih.gov/pubmed/33158956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000006
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