Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia

Anemias of chronic disease and inflammation (ACDI) result from restricted iron delivery to erythroid progenitors. The current studies reveal an organellar response in erythroid iron restriction consisting of disassembly of the microtubule cytoskeleton and associated Golgi disruption. Isocitrate supp...

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Publicado no:Nat Commun
Principais autores: Goldfarb, Adam N., Freeman, Katie C., Sahu, Ranjit K., Elagib, Kamaleldin E., Holy, Maja, Arneja, Abhinav, Polanowska-Grabowska, Renata, Gru, Alejandro A., White, Zollie, Khalil, Shadi, Kerins, Michael J., Ooi, Aikseng, Leitinger, Norbert, Luckey, Chance John, Delehanty, Lorrie L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7955080/
https://ncbi.nlm.nih.gov/pubmed/33712594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21938-2
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