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A specialized pathway for erythroid iron delivery through lysosomal trafficking of transferrin receptor 2

Erythroid progenitors are the largest consumers of iron in the human body. In these cells, a high flux of iron must reach the mitochondrial matrix to form sufficient heme to support hemoglobinization. Canonical erythroid iron trafficking occurs via the first transferrin receptor (TfR1)-mediated endo...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Khalil, Shadi, Holy, Maja, Grado, Stephen, Fleming, Robert, Kurita, Ryo, Nakamura, Yukio, Goldfarb, Adam
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728310/
https://ncbi.nlm.nih.gov/pubmed/29296759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016003772
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