Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice

The mechanisms underlying thrombocytosis in patients with iron deficiency anemia remain unknown. Here, we present findings that support the hypothesis that low iron biases the commitment of megakaryocytic (Mk)-erythroid progenitors (MEPs) toward the Mk lineage in both human and mouse. In MEPs of tra...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Xavier-Ferrucio, Juliana, Scanlon, Vanessa, Li, Xiuqi, Zhang, Ping-Xia, Lozovatsky, Larisa, Ayala-Lopez, Nadia, Tebaldi, Toma, Halene, Stephanie, Cao, Chang, Fleming, Mark D., Finberg, Karin E., Krause, Diane S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Red Cells, Iron, and Erythropoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839952/
https://ncbi.nlm.nih.gov/pubmed/31439541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002039
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