Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice

The mechanisms underlying thrombocytosis in patients with iron deficiency anemia remain unknown. Here, we present findings that support the hypothesis that low iron biases the commitment of megakaryocytic (Mk)-erythroid progenitors (MEPs) toward the Mk lineage in both human and mouse. In MEPs of tra...

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發表在:Blood
Main Authors: Xavier-Ferrucio, Juliana, Scanlon, Vanessa, Li, Xiuqi, Zhang, Ping-Xia, Lozovatsky, Larisa, Ayala-Lopez, Nadia, Tebaldi, Toma, Halene, Stephanie, Cao, Chang, Fleming, Mark D., Finberg, Karin E., Krause, Diane S.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2019
主題:
Red Cells, Iron, and Erythropoiesis
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839952/
https://ncbi.nlm.nih.gov/pubmed/31439541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002039
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