NCOA4 is regulated by HIF and mediates mobilization of murine hepatic iron stores after blood loss

The mechanisms by which phlebotomy promotes the mobilization of hepatic iron stores are not well understood. NCOA4 (nuclear receptor coactivator 4) is a widely expressed intracellular protein previously shown to mediate the autophagic degradation of ferritin. Here, we investigate a local requirement...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Li, Xiuqi, Lozovatsky, Larisa, Sukumaran, Abitha, Gonzalez, Luis, Jain, Anisha, Liu, Dong, Ayala-Lopez, Nadia, Finberg, Karin E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735158/
https://ncbi.nlm.nih.gov/pubmed/32659785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006321
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