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Fetal liver hepcidin secures iron stores in utero
In the adult, the liver-derived hormone hepcidin (HAMP) controls systemic iron levels by blocking the iron-exporting protein ferroportin (FPN) in the gut and spleen, the sites of iron absorption and recycling, respectively. Impaired HAMP expression or FPN responsiveness to HAMP result in iron overlo...
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| Publicado en: | Blood |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7515687/ https://ncbi.nlm.nih.gov/pubmed/32542311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003907 |
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