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Fetal liver hepcidin secures iron stores in utero
In the adult, the liver-derived hormone hepcidin (HAMP) controls systemic iron levels by blocking the iron-exporting protein ferroportin (FPN) in the gut and spleen, the sites of iron absorption and recycling, respectively. Impaired HAMP expression or FPN responsiveness to HAMP result in iron overlo...
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| Publicat a: | Blood |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7515687/ https://ncbi.nlm.nih.gov/pubmed/32542311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003907 |
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