Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice

The mechanisms underlying thrombocytosis in patients with iron deficiency anemia remain unknown. Here, we present findings that support the hypothesis that low iron biases the commitment of megakaryocytic (Mk)-erythroid progenitors (MEPs) toward the Mk lineage in both human and mouse. In MEPs of tra...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Xavier-Ferrucio, Juliana, Scanlon, Vanessa, Li, Xiuqi, Zhang, Ping-Xia, Lozovatsky, Larisa, Ayala-Lopez, Nadia, Tebaldi, Toma, Halene, Stephanie, Cao, Chang, Fleming, Mark D., Finberg, Karin E., Krause, Diane S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2019
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839952/
https://ncbi.nlm.nih.gov/pubmed/31439541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002039
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