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Characterization of human adrenal cytochrome P450 11B2 products of progesterone and androstenedione oxidation

Cytochrome P450 (P450) 11B1 and 11B2 both catalyze the 11β-hydroxylation of 11-deoxycorticosterone and the subsequent 18-hydroxylation of the product. P450 11B2, but not P450 11B1, catalyzes a further C-18 oxidation to yield aldosterone. 11-Oxygenated androgens are of interest, and 11-hydroxy proges...

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Dades bibliogràfiques
Publicat a:J Steroid Biochem Mol Biol
Autors principals: Glass, Sarah M., Reddish, Michael J., Child, Stella A., Wilkey, Clayton J., Stec, Donald F., Guengerich, F. Peter
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954869/
https://ncbi.nlm.nih.gov/pubmed/33189850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2020.105787
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