Androstenedione Is the Preferred Substrate for Cytochrome P450 11β-hydroxylase Leading to the Production of 11β-Hydroxyandrostenedione in the Adrenal Gland

Adrenal cytochrome P450 11β-hydroxylase (CYP11B1) is a mitochondrial enzyme that catalyzes the final step of glucocorticoid synthesis, converting 11-deoxycortisol (S) and deoxycorticosterone (DOC) to cortisol (F) and corticosterone (CORT), respectively. CYP11B1 is predominantly located in the zona f...

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Vydáno v:J Endocr Soc
Hlavní autoři: Barbier, Inge Doney, Gent, Rachelle, Du Toit, Therina, Swart, Amanda C
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Adrenal
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090357/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.132
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