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Characterization of human adrenal cytochrome P450 11B2 products of progesterone and androstenedione oxidation
Cytochrome P450 (P450) 11B1 and 11B2 both catalyze the 11β-hydroxylation of 11-deoxycorticosterone and the subsequent 18-hydroxylation of the product. P450 11B2, but not P450 11B1, catalyzes a further C-18 oxidation to yield aldosterone. 11-Oxygenated androgens are of interest, and 11-hydroxy proges...
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| Publicado no: | J Steroid Biochem Mol Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7954869/ https://ncbi.nlm.nih.gov/pubmed/33189850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2020.105787 |
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