Protein context shapes the specificity of SH3 domain-mediated interactions in vivo

Protein–protein interactions (PPIs) between modular binding domains and their target peptide motifs are thought to largely depend on the intrinsic binding specificities of the domains. The large family of SRC Homology 3 (SH3) domains contribute to cellular processes via their ability to support such...

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Publicado en:Nat Commun
Autores principales: Dionne, Ugo, Bourgault, Émilie, Dubé, Alexandre K., Bradley, David, Chartier, François J. M., Dandage, Rohan, Dibyachintan, Soham, Després, Philippe C., Gish, Gerald D., Pham, N. T. Hang, Létourneau, Myriam, Lambert, Jean-Philippe, Doucet, Nicolas, Bisson, Nicolas, Landry, Christian R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954794/
https://ncbi.nlm.nih.gov/pubmed/33712617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21873-2
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