Structure and selectivity engineering of the M(1) muscarinic receptor toxin complex

Muscarinic toxins (MTs) are natural toxins produced by mamba snakes that primarily bind to muscarinic acetylcholine receptors (MAChRs) and modulate their function. Despite their similar primary and tertiary structures, MTs show distinct binding selectivity toward different MAChRs. The molecular deta...

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Publicado en:Science
Main Authors: Maeda, Shoji, Xu, Jun, Kadji, Francois Marie N., Clark, Mary J., Zhao, Jiawei, Tsutsumi, Naotaka, Aoki, Junken, Sunahara, Roger K., Inoue, Asuka, Garcia, K Christopher, Kobilka, Brian K.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954660/
https://ncbi.nlm.nih.gov/pubmed/32646996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax2517
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