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Structure and selectivity engineering of the M(1) muscarinic receptor toxin complex
Muscarinic toxins (MTs) are natural toxins produced by mamba snakes that primarily bind to muscarinic acetylcholine receptors (MAChRs) and modulate their function. Despite their similar primary and tertiary structures, MTs show distinct binding selectivity toward different MAChRs. The molecular deta...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7954660/ https://ncbi.nlm.nih.gov/pubmed/32646996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax2517 |
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