Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral spike. While RBD-directed antibodies have been extensively studied, far less is known about NTD-directed antibodies. He...

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Publicat a:Cell Host Microbe
Autors principals: Cerutti, Gabriele, Guo, Yicheng, Zhou, Tongqing, Gorman, Jason, Lee, Myungjin, Rapp, Micah, Reddem, Eswar R., Yu, Jian, Bahna, Fabiana, Bimela, Jude, Huang, Yaoxing, Katsamba, Phinikoula S., Liu, Lihong, Nair, Manoj S., Rawi, Reda, Olia, Adam S., Wang, Pengfei, Zhang, Baoshan, Chuang, Gwo-Yu, Ho, David D., Sheng, Zizhang, Kwong, Peter D., Shapiro, Lawrence
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Inc. 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953435/
https://ncbi.nlm.nih.gov/pubmed/33789084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2021.03.005
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