Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

Antibodies that potently neutralize SARS-CoV-2 target mainly the receptor-binding domain or the N-terminal domain (NTD). Over a dozen potently neutralizing NTD-directed antibodies have been studied structurally, and all target a single antigenic supersite in NTD (site 1). Here we report the 3.7 Å re...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Cerutti, Gabriele, Guo, Yicheng, Wang, Pengfei, Nair, Manoj S., Huang, Yaoxing, Yu, Jian, Liu, Lihong, Katsamba, Phinikoula S., Bahna, Fabiana, Reddem, Eswar R., Kwong, Peter D., Ho, David D., Sheng, Zizhang, Shapiro, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259903/
https://ncbi.nlm.nih.gov/pubmed/34230927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.06.29.450397
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