Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP’s Inverse Agonist Pharmacology at the hMC4R

The melanocortin receptors (MCRs) are important for numerous biological pathways, including feeding behavior and energy homeostasis. In addition to endogenous peptide agonists, this receptor family has two naturally occurring endogenous antagonists, agouti and agouti-related protein (AGRP). At the m...

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Publicado no:ACS Chem Neurosci
Main Authors: Ericson, Mark D., Haslach, Erica M., Schnell, Sathya M., Freeman, Katie T., Xiang, Zhimin M., Portillo, Frederico P., Speth, Robert, Litherland, Sally A., Haskell-Luevano, Carrie
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951137/
https://ncbi.nlm.nih.gov/pubmed/33470098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00755
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