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Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP’s Inverse Agonist Pharmacology at the hMC4R

The melanocortin receptors (MCRs) are important for numerous biological pathways, including feeding behavior and energy homeostasis. In addition to endogenous peptide agonists, this receptor family has two naturally occurring endogenous antagonists, agouti and agouti-related protein (AGRP). At the m...

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發表在:ACS Chem Neurosci
Main Authors: Ericson, Mark D., Haslach, Erica M., Schnell, Sathya M., Freeman, Katie T., Xiang, Zhimin M., Portillo, Frederico P., Speth, Robert, Litherland, Sally A., Haskell-Luevano, Carrie
格式: Artigo
語言:Inglês
出版: 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951137/
https://ncbi.nlm.nih.gov/pubmed/33470098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00755
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